abstract：:The physicochemical properties of 4-α-glucanotransferase (4αGTase)-modified rice flours were examined by measuring the molecular weight distribution, moisture sorption isotherm, and melting enthalpy of ice crystals. The results obtained by measuring the moisture sorption isotherm and melting enthalpy of ice crystals r...

journal_title：International journal of biological macromolecules

authors： Kim YL,Mun S,Park KH,Shim JY,Kim YR

更新日期：2013-09-01 00:00:00

abstract：:In the present investigation an attempt has been made to develop a new co-polymeric material for controlled release tablet formulations. The acrylamide grafting was successfully performed on the backbone of sago starch. The modified starch was tested for acute toxicity and drug-excipient compatibility study. The graft...

journal_title：International journal of biological macromolecules

authors： Singh AV,Nath LK

更新日期：2013-09-01 00:00:00

abstract：:The soybean protein was hydrolyzed by Alcalase Food grade (FG) 2.4 L and the optimal hydrolysis parameters of strongest antioxidant capacity of peptides were obtained using response surface methodology (RSM). The effects of reaction temperature, pH value and ratio of enzyme/soybean protein powder ([E/S]) on the 2,2-di...

journal_title：International journal of biological macromolecules

authors： Lin S,Wang J,Zhao P,Pang Y,Ye H,Yuan Y,Liu J,Jones G

更新日期：2013-08-01 00:00:00

abstract：:Acetylated corn starch (ACS) was synthesized by the reaction of native corn starch (NCS) with acetic anhydride (AA) and acetic acid in an aqueous medium in the presence of p-toluenesulfonic acid (PTSA) as a catalyst. The factors that could affect the degree of substitution (DS) of corn starch were investigated which i...

journal_title：International journal of biological macromolecules

authors： Han F,Gao C,Liu M,Huang F,Zhang B

更新日期：2013-08-01 00:00:00

abstract：:The study aims at formulation and optimization brain targeted nanoparticles (NP) of Rivastigmine (RT) to improve its therapeutic potential and to verify its safety profile. The NP were optimized using a two factor three level (3(2)) central composite design aiming to minimize particle size; maximize zeta potential and...

journal_title：International journal of biological macromolecules

authors： Nagpal K,Singh SK,Mishra DN

更新日期：2013-08-01 00:00:00

abstract：:The potential gastroprotection of polysaccharides (SP) isolated from maté (Ilex paraguariensis) leaves of different growth stages, under different sunlight conditions and of processing methods were evaluated. The SP consist of type I arabinogalactan (AG1) containing a (1→4)-linked β-Galp chain, with substituents of ar...

journal_title：International journal of biological macromolecules

authors： Maria-Ferreira D,Dartora N,da Silva LM,Pereira IT,de Souza LM,Ritter DS,Iacomini M,Werner MF,Sassaki GL,Baggio CH

更新日期：2013-08-01 00:00:00

abstract：:Starch retrogradation is the main cause of quality deterioration of starch-containing foods during storage. The purpose of this study is to find out whether certain soy protein polypeptide in hydrolysates will retard maize starch retrogradation. The results show that all soy protein hydrolysates retard maize starch re...

journal_title：International journal of biological macromolecules

authors： Lian X,Zhu W,Wen Y,Li L,Zhao X

更新日期：2013-08-01 00:00:00

abstract：:Lectins are carbohydrate recognition proteins. cMoL, a coagulant Moringa oleifera Lectin, was isolated from seeds of the plant. Structural studies revealed a heat-stable and pH resistant protein with 101 amino acids, 11.67 theoretical pI and 81% similarity with a M. oleifera flocculent protein. Secondary structure con...

journal_title：International journal of biological macromolecules

authors： Luz Lde A,Silva MC,Ferreira Rda S,Santana LA,Silva-Lucca RA,Mentele R,Oliva ML,Paiva PM,Coelho LC

更新日期：2013-07-01 00:00:00

abstract：:Biodegradable flocculants of Gum ghatti (Gg) with acrylamide (AAm) were prepared through graft co-polymerization technique using potassium persulphate (KPS)-ascorbic acid (ABC) redox pair as initiator and N,N'-methylene-bis-acrylamide (MBA) as a crosslinker. Gg-cl-poly(AAm) was found to exhibit pH and temperature resp...

journal_title：International journal of biological macromolecules

authors： Mittal H,Mishra SB,Mishra AK,Kaith BS,Jindal R

更新日期：2013-07-01 00:00:00

abstract：:Arginine kinase (AK) plays a key role in ATP buffering systems of tissues and nerves that display high and variable rates of ATP turnover and is widely distributed in invertebrate animals. The enzyme is also found in unicellular organisms, protists and bacteria, but its occurrence is intermittent among species. The AK...

journal_title：International journal of biological macromolecules

authors： Suzuki T,Soga S,Inoue M,Uda K

更新日期：2013-06-01 00:00:00

abstract：:It is reported that apple polysaccharide can prevent colon cancer growth and impede colon cancer progression. Apple oligosaccharide was prepared by the combination of alkaline hydrolysis and enzymolysis of apple polysaccharides, and purified by anion column chromatography. The aim of this study is to explore the effec...

journal_title：International journal of biological macromolecules

authors： Li Q,Zhou S,Jing J,Yang T,Duan S,Wang Z,Mei Q,Liu L

更新日期：2013-06-01 00:00:00

abstract：:We investigated the lipid lowering ability of simvastatin loaded gellan gum-carrageenan composite polyspheres, which were prepared by ionotropic gelation/covalent crosslinking method. The surface morphology revealed that the polyspheres have rough and dense surface. The drug entrapment efficiency of the polyspheres pr...

journal_title：International journal of biological macromolecules

authors： Kulkarni RV,Nagathan VV,Biradar PR,Naikawadi AA

更新日期：2013-06-01 00:00:00

abstract：:Myelin basic protein (MBP) is one of the main protein components of central nervous system that as shown in our work, under appropriate condition, forms spherulites. The structural and morphological features of these elements and the ability of trehalose to decrease or completely avoid their formation have been clarif...

journal_title：International journal of biological macromolecules

authors： Di Salvo C,Barreca D,Laganà G,di Bella M,Tellone E,Ficarra S,Bellocco E

更新日期：2013-06-01 00:00:00

abstract：:Coriolus versicolor has been known to be an immune stimulator effects. For further understanding of the phagocytic activity and the intracellular mechanisms of β-glucan from C. versicolor (CVG), we examined the phagocytic activity, phosphorylation of Akt and CK2, nucleus translocation of p65 and Ikaros activity in β-g...

journal_title：International journal of biological macromolecules

authors： Kang SC,Koo HJ,Park S,Lim JD,Kim YJ,Kim T,Namkoong S,Jang KH,Pyo S,Jang SA,Sohn EH

更新日期：2013-06-01 00:00:00

abstract：:A total of 18 protease producing bacterial strains were isolated from detergent effluent in South Korea using skim milk agar medium. A strain (BK-P21A) was selected and identified as Bacillus koreensis based on morphological, biochemical and molecular characterizations (16S rRNA gene sequence analysis). Optimized cult...

journal_title：International journal of biological macromolecules

authors： Anbu P

更新日期：2013-05-01 00:00:00

abstract：:The structure changes of hemoglobin (Hb) and glucose oxidase (GOx), as two typical proteins, upon interaction with MWCNTs and MWCNTs-[BMIM]BF₄(-) was studied. The ability of MWCNTs and MWCNTs-([BMIM]BF₄(-)) for the achievement of direct electrochemistry of GOx and Hb and enhancing the electron transfer rate between pr...

journal_title：International journal of biological macromolecules

authors： Karimi S,Ghourchian H,Banaei A

更新日期：2013-05-01 00:00:00

abstract：:The Ca(2+)-induced conformational changes in calmodulin (CaM) were monitored by Fourier transform infrared spectroscopy (FT-IR) at different molar ratios of Ca(2+) to CaM. The results show that these changes occur in two distinctive transitions. The first transition involves significant changes in the overall secondar...

journal_title：International journal of biological macromolecules

authors： Yu T,Wu G,Yang H,Wang J,Yu S

更新日期：2013-05-01 00:00:00

abstract：:An alkaline serine protease from a newly isolated salt-tolerant alkaliphilic actinomycetes, Brachystreptospora xinjiangensis OM-6 was purified with 35- and 26-fold purification and 47% and 22% yield employing two steps and one step methods, respectively. The enzyme was quite stable at 80 °C in 30% Na-glutamate with th...

journal_title：International journal of biological macromolecules

authors： Gohel SD,Singh SP

更新日期：2013-05-01 00:00:00

abstract：:For the cholesterol oxidase from Brevibacterium sp. M201008 was not stable as free enzyme form, it had been covalently immobilized onto functionalized sepharose particles that were activated with N-ethyl-N'-3-dimethylaminopropyl carbodiimide (EDC).The optimal conditions of enzyme immobilization were determined, and th...

journal_title：International journal of biological macromolecules

authors： Chen Y,Xin Y,Yang H,Zhang L,Zhang Y,Xia X,Tong Y,Wang W

更新日期：2013-05-01 00:00:00

abstract：:The objective of this study was to prepare and characterize chitosan-magnesium aluminum silicate (CS-MAS) nanocomposite films as a buccal delivery system for nicotine (NCT). The effects of the CS-MAS ratio on the physicochemical properties, release and permeation, as well as on the mucoadhesive properties, were invest...

journal_title：International journal of biological macromolecules

authors： Pongjanyakul T,Khunawattanakul W,Strachan CJ,Gordon KC,Puttipipatkhachorn S,Rades T

更新日期：2013-04-01 00:00:00

abstract：:The study involves mucoadhesive evaluation by formulating buccal discs using fluconazole as the model drug. The effect of compression pressure and gum cordia/lactose ratio on the ex vivo bioadhesion time and in vitro release of fluconazole was optimized using central composite experimental design. It was observed that...

journal_title：International journal of biological macromolecules

authors： Ahuja M,Kumar S,Kumar A

更新日期：2013-04-01 00:00:00

abstract：:A series of negatively charged macromolecules (NCMs) including poly (sulfonated styrene-co-methyl methacrylate) (P(SS-co-MMA)), poly (acrylic acid-co-methyl methacrylate) (P(AA-co-MMA)) and poly (sulfonated styrene-co-acrylic acid-co-methyl methacrylate) (P(SS-co-AA-co-MMA)) are synthesized by reversible addition frag...

journal_title：International journal of biological macromolecules

authors： Ran F,Nie S,Yin Z,Li J,Su B,Sun S,Zhao C

更新日期：2013-04-01 00:00:00

abstract：:Amylopectin is a highly branched starch component built up of a large number of clustered α-D-glucose chains. A single C-chain possesses the reducing end and carries the rest of the macromolecule. The aim of this study was to investigate the interconnection of clusters and domains (groups of clusters) in barley amylop...

journal_title：International journal of biological macromolecules

authors： Källman A,Bertoft E,Koch K,Åman P,Andersson R

更新日期：2013-04-01 00:00:00

abstract：:Pullulan is a thickener that can form semipermeable films, and glutathione is an effective reducing agent, while chitooligosaccharide has antibacterial activity. In this study, effect of pullulan-based coatings in combination with antibrowning and antibacterial agents (1% pullulan; 0.8% glutathione+1% chitooligosaccha...

journal_title：International journal of biological macromolecules

authors： Wu S,Chen J

更新日期：2013-04-01 00:00:00

abstract：:Fibrinogen (Fg) also known as coagulation factor I represents about 4% of the total human plasma proteins. The main function of Fg is its involvement in last phase of blood coagulation cascade, when thrombin-induced conversion of dissolved plasma fibrinogen into an insoluble fibrin clot occurs. The reaction of fibrino...

journal_title：International journal of biological macromolecules

authors： Bijak M,Saluk J,Antosik A,Ponczek MB,Żbikowska HM,Borowiecka M,Nowak P

更新日期：2013-04-01 00:00:00

abstract：:Three 4-(1H-imidazo[4,5-f]-1,10-phenanthrolin-2-yl)phenol derivatives-based platinum (II) complexes have been synthesized, and their G-quadruplex DNAs-binding interactions, telomerase inhibition, antiproliferative activity, and cell cycle arrest were studied. Three complexes show the preference for stabilizing h-telo,...

journal_title：International journal of biological macromolecules

authors： Wei C,Wen Y,Wang J

更新日期：2013-04-01 00:00:00

abstract：:In continuation of our previous work, a novel series of polycyclic derivatives 2-8 incorporated heterocyclic and sugar moieties were synthesized by using pyren-1-aldehyde (1) as starting material and their tested as antiviral activities. Initially, the toxicity of the compounds was assayed via the determination of the...

journal_title：International journal of biological macromolecules

authors： Khalifa NM,Al-Omar MA,Amr Ael-G,Haiba ME

更新日期：2013-03-01 00:00:00

abstract：:The present study is to explore the optimal extraction parameters and liver protective effect of the polygonatum polysaccharides in vivo. The order of factor effects on polysaccharides production was found to be extraction time (min, A)>ratio of solvent to solid (C)>extraction temperature (°C, B)>extraction number (D)...

journal_title：International journal of biological macromolecules

authors： Jiang Q,Lv Y,Dai W,Miao X,Zhong D

更新日期：2013-03-01 00:00:00

abstract：:Cellulose acetate nanofibrous mats were prepared by electrospunning technique. Positively charged and negatively charged composites were alternately deposited on negatively charged CA mats via layer-by-layer self-assembly technique. The morphology and inhibition rate of samples were investigated by regulating number o...

journal_title：International journal of biological macromolecules

authors： Huang W,Li X,Xue Y,Huang R,Deng H,Ma Z

更新日期：2013-02-01 00:00:00

abstract：:To investigate the molecular features responsible for protein halophilicity is of great significance for understanding the structure basis of protein halo-stability and would help to develop a practical strategy for designing halophilic proteins. In this work, we have systematically analyzed the dipeptide composition ...

journal_title：International journal of biological macromolecules

authors： Zhang G,Huihua G,Yi L

更新日期：2013-02-01 00:00:00

abstract：:Metagenomics has opened new horizon to unlock the biotechnological potential for novel enzymes. An alkaline protease gene was obtained from the total environmental DNA extracted from a saline habitat. After cloning and sequencing, it was identified that the protease gene related to uncultivable bacteria (HM219181). Th...

journal_title：International journal of biological macromolecules

authors： Purohit MK,Singh SP

更新日期：2013-02-01 00:00:00

abstract：:Concanavalin A (Con A) binding fraction of human seminal plasma is vital as it shows decapacitating activity and contains proteins which have critical roles in fertility related processes. Con A binding proteins were isolated by lectin affinity chromatography. These proteins form high molecular weight aggregates at ne...

journal_title：International journal of biological macromolecules

authors： Tomar AK,Sooch BS,Singh S,Yadav S

更新日期：2013-02-01 00:00:00

abstract：:Twelve therapeutic mAbs, comprising 10 IgG1s and 2 IgG4s, were analyzed by a peptide mapping technique to detect and quantify C-terminal modifications. C-terminal amidated structures were found in 8 out of the 12 mAbs. An in vitro study using a commercially available peptidylglycine alpha-amidating monooxygenase (PAM)...

journal_title：International journal of biological macromolecules

authors： Tsubaki M,Terashima I,Kamata K,Koga A

更新日期：2013-01-01 00:00:00

abstract：:Hericium erinaceus polysaccharide (HEP) is a traditional Chinese medicine. In the present study, chemical composition and antioxidant activity of HEP was investigated. HPLC analysis showed that the HEP was composed of xylose (7.8%), ribose (2.7%), glucose (68.4%), arabinose (11.3%), galactose (2.5%) and mannose (5.2%)...

journal_title：International journal of biological macromolecules

authors： Han ZH,Ye JM,Wang GF

更新日期：2013-01-01 00:00:00

abstract：:Chitosan, a naturally occurring biopolymer, has received considerable attention for pharmaceutical applications due to its biocompatible, biodegradable and less toxic properties. In this study, sulfated chitooligosaccharides (COS-S) with different degrees of substitution (DS) were prepared to improve both its water-so...

journal_title：International journal of biological macromolecules

authors： Lu X,Guo H,Sun L,Zhang L,Zhang Y

更新日期：2013-01-01 00:00:00

abstract：:Possible roles of two different Arginine (Arg; R) 213 and 337 on kinetic and structural stability of Photinus pyralis luciferase have been investigated using thermal and chemical denaturation studies. This enzyme is highly sensitive to protease digestion and temperature, which limits its fieldability, particularly for...

journal_title：International journal of biological macromolecules

authors： Riahi-Madvar A,Hosseinkhani S,Rezaee F

更新日期：2013-01-01 00:00:00

abstract：:This study aims to investigate the effect of nitrogen source on curdlan production by Alcaligenes faecalis ATCC 31749. Curdlan production fell when excess nitrogen source was present, while biomass accumulation increased as the level of nitrogen source raised. Curdlan production and biomass accumulation were greater w...

journal_title：International journal of biological macromolecules

authors： Jiang L

更新日期：2013-01-01 00:00:00

abstract：:A polyether-urethane based on polytetrahydrofuran containing hydroxypropyl cellulose for biomedical applications was tested for its biocompatibility. Ketoprofen was incorporated (3% and 6%) in the polyurethane matrix as an anti-inflammatory drug. Dynamic vapour sorption method was employed for testing the water sorpti...

journal_title：International journal of biological macromolecules

authors： Macocinschi D,Filip D,Vlad S,Butnaru M,Knieling L

更新日期：2013-01-01 00:00:00

abstract：:The role of polyglutamine (polyQ) tract on protein stability and disease pathology remains ambiguous. We monitored the unfolding/refolding patterns of huntingtin proteins with varying polyQ lengths. In the presence of urea, minor differences in unfolding and refolding efficiencies were observed. However, in the presen...

journal_title：International journal of biological macromolecules

authors： Vachharajani SN,Chaudhary RK,Prasad S,Roy I

更新日期：2012-12-01 00:00:00

abstract：:The purpose of the present study was to synthesize gum kondagogu-g-poly(N-vinyl-2-pyrrolidone) and to evaluate its mucoadhesive properties. UV-assisted graft co-polymerization of N-vinyl-2-pyrrolidone on gum kondagogu was carried out employing three-factor, three-level central composite experimental designs. It was ob...

journal_title：International journal of biological macromolecules

authors： Malik S,Kumar A,Ahuja M

更新日期：2012-12-01 00:00:00